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KMID : 0357019960120010001
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Journal of the Korean Vascular Surgery Society
1996 Volume.12 No. 1 p.1 ~ p.10
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The Effect of Cytokines on Proliferation and Expression of HLA-DR, ICAM-1 and VCAM in Cultured Human Vascular Smooth Muscle Cells
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Abstract
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This present study focused on the question of whether the expression of HLA-DR, intracelluar adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule(VCAM) and proliferation of cultured human vascular smooth muscle cells(SMC), stimulated
with
interleukin-1β(IL-1β), interleukin-4(IL-4), interferon-γ(IFN-γ), tumor necrosis factor-α(TNF-α) and platelet derived growth factor(PDGF). Stimulation of SMC with IFN-γ induced marked expression of human leukocyte antigen-DR(HLA-DR). IL-4
and
TNF-α did not stimulated HLA-DR expression of cultured SMC. Expression of ICAM-1 in cultured SMC was stimulated with IFNα and TNF-α but did not increased with IL-1β and IL-4. Expression of VCAM in cultured SMC was markedly increased in
stimulation
with IL-4, and also increased in stimulation with TNF-α but no expression was observed in stimulation with IFN-γ. Stimulation with IL-1β and PDGF induced marked proliferation of SM, and reduction of proliferation with IFN-γ.
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KEYWORD
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